Cargando…

Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease

Cerebrovascular dysfunction contributes to the pathology and progression of Alzheimer's disease (AD), but the mechanisms are not completely understood. Using transgenic mouse models of AD (TgCRND8, PDAPP, and Tg2576), we evaluated blood–brain barrier damage and the role of fibrin and fibrinolys...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paul, Justin, Strickland, Sidney, Melchor, Jerry P.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118680/ https://www.ncbi.nlm.nih.gov/pubmed/17664291 http://dx.doi.org/10.1084/jem.20070304

Ejemplares similares

Neurovascular dysfunction and neuroinflammation in a Cockayne syndrome mouse model
por: Kajitani, Gustavo Satoru, et al.
Publicado: (2021)

Neuroinflammation in mouse models of Alzheimer's disease
por: Saito, Takashi, et al.
Publicado: (2018)

Platelets Recognize Brain-Specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation
por: Sotnikov, Ilya, et al.
Publicado: (2013)

The link between neuroinflammation and the neurovascular unit in synucleinopathies
por: Wang, Qing, et al.
Publicado: (2023)

Impaired Hippocampal Neurovascular Coupling in a Mouse Model of Alzheimer’s Disease
por: Li, Lin, et al.
Publicado: (2021)

Correction: Platelets Recognize Brain-Specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation
por: Sotnikov, Ilya, et al.
Publicado: (2014)

Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages
por: Stanciu, Gabriela Dumitrita, et al.
Publicado: (2020)

Neurovascular coupling preserved in a chronic mouse model of Alzheimer’s disease: Methodology is critical
por: Sharp, Paul S, et al.
Publicado: (2019)

On Fibrinous Deposition in the Heart
Publicado: (1863)

The role of neuroinflammation and neurovascular dysfunction in major depressive disorder
por: Jeon, Sang Won, et al.
Publicado: (2018)

Early Life Obesity Increases Neuroinflammation, Amyloid Beta Deposition, and Cognitive Decline in a Mouse Model of Alzheimer’s Disease
por: So, Simon W., et al.
Publicado: (2023)

Insoluble Vascular Amyloid Deposits Trigger Disruption of the Neurovascular Unit in Alzheimer’s Disease Brains
por: Soto-Rojas, Luis O., et al.
Publicado: (2021)

Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease
por: Shabir, Osman, et al.
Publicado: (2022)

Neuroinflammation and amyloid deposition in the progression of mixed Alzheimer and vascular dementia
por: Ying, Chunwei, et al.
Publicado: (2023)

Knee osteoarthritis accelerates amyloid beta deposition and neurodegeneration in a mouse model of Alzheimer’s disease
por: Gupta, Deepak Prasad, et al.
Publicado: (2023)

Effects of Voluntary Physical Exercise on the Neurovascular Unit in a Mouse Model of Alzheimer’s Disease
por: Andrade-Guerrero, Jesús, et al.
Publicado: (2023)

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease
por: Wright, Amanda L., et al.
Publicado: (2013)

Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer’s disease
por: Zhu, Winston M, et al.
Publicado: (2022)

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration
por: Ryu, Jae Kyu, et al.
Publicado: (2018)

Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit
por: Tohidpour, Abolghasem, et al.
Publicado: (2017)

Accelerated aging-related transcriptome alterations in neurovascular unit cells in the brain of Alzheimer’s disease
por: Zhao, Yan, et al.
Publicado: (2022)

The Neurovascular Unit Dysfunction in Alzheimer’s Disease
por: Soto-Rojas, Luis O., et al.
Publicado: (2021)

Ultrastructural Remodeling of the Blood–Brain Barrier and Neurovascular Unit by Lipopolysaccharide-Induced Neuroinflammation
por: Erickson, Michelle A., et al.
Publicado: (2023)

Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease
por: Sun, Xiao-ying, et al.
Publicado: (2021)

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model
por: Freitag, Kiara, et al.
Publicado: (2022)

TNFR1-JNK signaling is the shared pathway of neuroinflammation and neurovascular damage after LPS-sensitized hypoxic-ischemic injury in the immature brain
por: Wang, Lan-Wan, et al.
Publicado: (2014)

Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s disease
por: Lackie, Rachel E., et al.
Publicado: (2020)

Fibrin deposition associates with cartilage degeneration in arthritis
por: Hügle, Thomas, et al.
Publicado: (2022)

THE CONVERSION OF FIBRINOGEN TO FIBRIN : XIII. DISSOLUTION OF FIBRIN AND INHIBITION OF CLOTTING BY VARIOUS NEUTRAL SALTS
por: Shulman, Sidney, et al.
Publicado: (1953)

Rodent models of neuroinflammation for Alzheimer’s disease
por: Nazem, Amir, et al.
Publicado: (2015)

Neurovascular and neurometabolic derailment in aging and Alzheimer's disease
por: Lourenço, Cátia F., et al.
Publicado: (2015)

Neurovascular dysfunction in vascular dementia, Alzheimer’s and atherosclerosis
por: Shabir, Osman, et al.
Publicado: (2018)

Impact of Tau on Neurovascular Pathology in Alzheimer's Disease
por: Canepa, Elisa, et al.
Publicado: (2021)

Early neurovascular dysfunction in a transgenic rat model of Alzheimer’s disease
por: Joo, Illsung L., et al.
Publicado: (2017)

REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model
por: Luca, Lorenzini, et al.
Publicado: (2016)

IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model
por: Sohrabi, Mona, et al.
Publicado: (2020)

Ketogenic diet ameliorates cognitive impairment and neuroinflammation in a mouse model of Alzheimer’s disease
por: Xu, Yunlong, et al.
Publicado: (2021)

Dipeptide of ψ-GSH Inhibits Oxidative Stress and Neuroinflammation in an Alzheimer’s Disease Mouse Model
por: Raza, Abbas, et al.
Publicado: (2022)

Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction
por: Nzou, Goodwell, et al.
Publicado: (2020)

Early alterations of neurovascular unit in the retina in mouse models of tauopathy
por: Xia, Fan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ijkrhtb4vm314gq74d3dd7tpg8