The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection

Neutrophil serine proteases (NSPs; elastase, cathepsin G, and proteinase-3) directly kill invading microbes. However, excess NSPs in the lungs play a central role in the pathology of inflammatory pulmonary disease. We show that serpinb1, an efficient inhibitor of the three NSPs, preserves cell and m...

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Detalles Bibliográficos
Autores principales: Benarafa, Charaf, Priebe, Gregory P., Remold-O'Donnell, Eileen
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118684/
https://www.ncbi.nlm.nih.gov/pubmed/17664292
http://dx.doi.org/10.1084/jem.20070494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118684/
https://www.ncbi.nlm.nih.gov/pubmed/17664292
http://dx.doi.org/10.1084/jem.20070494

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