Cargando…
Requirement for T-bet in the aberrant differentiation of unhelped memory CD8(+) T cells
Immunity to intracellular pathogens requires dynamic balance between terminal differentiation of short-lived, cytotoxic effector CD8(+) T cells and self-renewal of central–memory CD8(+) T cells. We now show that T-bet represses transcription of IL-7Rα and drives differentiation of effector and effec...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118697/ https://www.ncbi.nlm.nih.gov/pubmed/17698591 http://dx.doi.org/10.1084/jem.20070841 |