Progressive CD4(+) central–memory T cell decline results in CD4(+) effector–memory insufficiency and overt disease in chronic SIV infection

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Primary simian immunodeficiency virus (SIV) infections of rhesus macaques result in the dramatic depletion of CD4(+) CCR5(+) effector–memory T (T(EM)) cells from extra-lymphoid effector sites, but in most infections, an increased rate of CD4(+) memory T cell proliferation appears to prevent collapse...

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Detalles Bibliográficos
Autores principales: Okoye, Afam, Meier-Schellersheim, Martin, Brenchley, Jason M., Hagen, Shoko I., Walker, Joshua M., Rohankhedkar, Mukta, Lum, Richard, Edgar, John B., Planer, Shannon L., Legasse, Alfred, Sylwester, Andrew W., Piatak, Michael, Lifson, Jeffrey D., Maino, Vernon C., Sodora, Donald L., Douek, Daniel C., Axthelm, Michael K., Grossman, Zvi, Picker, Louis J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118701/
https://www.ncbi.nlm.nih.gov/pubmed/17724130
http://dx.doi.org/10.1084/jem.20070567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118701/
https://www.ncbi.nlm.nih.gov/pubmed/17724130
http://dx.doi.org/10.1084/jem.20070567

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