COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARδ activation

Although cyclooxygenase (COX)-2 inhibitors (coxibs) are effective in controlling inflammation, pain, and tumorigenesis, their use is limited by the recent revelation of increased adverse cardiovascular events. The mechanistic basis of this side effect is not well understood. We show that the metabol...

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Detalles Bibliográficos
Autores principales: Ghosh, Mallika, Wang, Haibin, Ai, Youxi, Romeo, Elisa, Luyendyk, James P., Peters, Jeffrey M., Mackman, Nigel, Dey, Sudhansu K., Hla, Timothy
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118704/
https://www.ncbi.nlm.nih.gov/pubmed/17724132
http://dx.doi.org/10.1084/jem.20070828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118704/
https://www.ncbi.nlm.nih.gov/pubmed/17724132
http://dx.doi.org/10.1084/jem.20070828

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