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Th1/Th2 cross-regulation and the discovery of IL-10
In the late 1980s, Tim Mosmann and colleagues isolated functionally distinct T helper (Th)-1 and Th2 clones, and provided evidence that these two subsets were mutually inhibitory. Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells.
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| Formato: | Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118739/ https://www.ncbi.nlm.nih.gov/pubmed/17354288 http://dx.doi.org/10.1084/jem.2042fta |