Th1/Th2 cross-regulation and the discovery of IL-10

In the late 1980s, Tim Mosmann and colleagues isolated functionally distinct T helper (Th)-1 and Th2 clones, and provided evidence that these two subsets were mutually inhibitory. Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells.

Detalles Bibliográficos
Autor principal: Bashyam, Hema
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
From the Archive
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118739/
https://www.ncbi.nlm.nih.gov/pubmed/17354288
http://dx.doi.org/10.1084/jem.2042fta
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author Bashyam, Hema
author_facet Bashyam, Hema
author_sort Bashyam, Hema
collection PubMed
description In the late 1980s, Tim Mosmann and colleagues isolated functionally distinct T helper (Th)-1 and Th2 clones, and provided evidence that these two subsets were mutually inhibitory. Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells.
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spelling pubmed-21187392007-12-13 Th1/Th2 cross-regulation and the discovery of IL-10 Bashyam, Hema J Exp Med From the Archive In the late 1980s, Tim Mosmann and colleagues isolated functionally distinct T helper (Th)-1 and Th2 clones, and provided evidence that these two subsets were mutually inhibitory. Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells. The Rockefeller University Press 2007-02-19 /pmc/articles/PMC2118739/ /pubmed/17354288 http://dx.doi.org/10.1084/jem.2042fta Text en Copyright © 2007, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle From the Archive
Bashyam, Hema
Th1/Th2 cross-regulation and the discovery of IL-10
title Th1/Th2 cross-regulation and the discovery of IL-10
title_full Th1/Th2 cross-regulation and the discovery of IL-10
title_fullStr Th1/Th2 cross-regulation and the discovery of IL-10
title_full_unstemmed Th1/Th2 cross-regulation and the discovery of IL-10
title_short Th1/Th2 cross-regulation and the discovery of IL-10
title_sort th1/th2 cross-regulation and the discovery of il-10
topic From the Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118739/
https://www.ncbi.nlm.nih.gov/pubmed/17354288
http://dx.doi.org/10.1084/jem.2042fta
work_keys_str_mv AT bashyamhema th1th2crossregulationandthediscoveryofil10

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