Anti-CD4 mediates clonal anergy during transplantation tolerance induction

Depletion of CD4+ cells using anti-CD4 monoclonal antibodies leads to allograft tolerance. Here we show that anti-CD4-mediated tolerance to pancreatic islets of Langerhans transplanted from an A/J (IEk) donor to a diabetic C57B1/6 (B6) (IE-) recipient occurs in the absence of clonal deletion of the...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118801/
https://www.ncbi.nlm.nih.gov/pubmed/1899105
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collection PubMed
description Depletion of CD4+ cells using anti-CD4 monoclonal antibodies leads to allograft tolerance. Here we show that anti-CD4-mediated tolerance to pancreatic islets of Langerhans transplanted from an A/J (IEk) donor to a diabetic C57B1/6 (B6) (IE-) recipient occurs in the absence of clonal deletion of the potentially IE-reactive V beta 11+ T cells. Instead, a state of clonal anergy is induced in both the CD4+V beta 11+ and CD8+V beta 11+ T cell subsets. This clonal anergy can be partially overcome in vitro by the addition of recombinant interleukin 2.
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spelling pubmed-21188012008-04-17 Anti-CD4 mediates clonal anergy during transplantation tolerance induction J Exp Med Articles Depletion of CD4+ cells using anti-CD4 monoclonal antibodies leads to allograft tolerance. Here we show that anti-CD4-mediated tolerance to pancreatic islets of Langerhans transplanted from an A/J (IEk) donor to a diabetic C57B1/6 (B6) (IE-) recipient occurs in the absence of clonal deletion of the potentially IE-reactive V beta 11+ T cells. Instead, a state of clonal anergy is induced in both the CD4+V beta 11+ and CD8+V beta 11+ T cell subsets. This clonal anergy can be partially overcome in vitro by the addition of recombinant interleukin 2. The Rockefeller University Press 1991-02-01 /pmc/articles/PMC2118801/ /pubmed/1899105 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Anti-CD4 mediates clonal anergy during transplantation tolerance induction
title Anti-CD4 mediates clonal anergy during transplantation tolerance induction
title_full Anti-CD4 mediates clonal anergy during transplantation tolerance induction
title_fullStr Anti-CD4 mediates clonal anergy during transplantation tolerance induction
title_full_unstemmed Anti-CD4 mediates clonal anergy during transplantation tolerance induction
title_short Anti-CD4 mediates clonal anergy during transplantation tolerance induction
title_sort anti-cd4 mediates clonal anergy during transplantation tolerance induction
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118801/
https://www.ncbi.nlm.nih.gov/pubmed/1899105

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