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Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide
Macrophage-derived nitric oxide (NO) is cytostatic to tumor cells and microbial pathogens. We tested whether one molecular target for the cytostatic action of NO may be ribonucleotide reductase (RR), a rate- limiting enzyme in DNA synthesis. In a concentration-dependent manner, NO gas and lysates of...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1991
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118959/ https://www.ncbi.nlm.nih.gov/pubmed/1717630 |