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Leukemia inhibitory factor improves survival of retroviral vector- infected hematopoietic stem cells in vitro, allowing efficient long- term expression of vector-encoded human adenosine deaminase in vivo
Low recovery and poor retroviral vector infection efficiency of hematopoietic stem cells has hindered application of gene therapy for disease affecting blood-forming tissues. Developmental restriction (or death) of stem cells during ex vivo infection has contributed to these difficulties. In these s...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1991
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118965/ https://www.ncbi.nlm.nih.gov/pubmed/1655947 |