Structural differences between the two human complement C4 isotypes affect the humoral immune response

An animal model has been used to address the question of the biological importance of the known structural difference between the two isotypes of human C4, i.e., C4A and C4B. Guinea pigs deficient in C4 were reconstituted transiently with either human C4A or C4B protein and immunized with the bacter...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1992
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119129/
https://www.ncbi.nlm.nih.gov/pubmed/1732415
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collection PubMed
description An animal model has been used to address the question of the biological importance of the known structural difference between the two isotypes of human C4, i.e., C4A and C4B. Guinea pigs deficient in C4 were reconstituted transiently with either human C4A or C4B protein and immunized with the bacteriophage phi X174. Results from this study showed that C4A-reconstituted animals made a secondary response, i.e., switch from IgM to IgG; whereas the C4B-reconstituted animals did not.
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spelling pubmed-21191292008-04-16 Structural differences between the two human complement C4 isotypes affect the humoral immune response J Exp Med Articles An animal model has been used to address the question of the biological importance of the known structural difference between the two isotypes of human C4, i.e., C4A and C4B. Guinea pigs deficient in C4 were reconstituted transiently with either human C4A or C4B protein and immunized with the bacteriophage phi X174. Results from this study showed that C4A-reconstituted animals made a secondary response, i.e., switch from IgM to IgG; whereas the C4B-reconstituted animals did not. The Rockefeller University Press 1992-02-01 /pmc/articles/PMC2119129/ /pubmed/1732415 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Structural differences between the two human complement C4 isotypes affect the humoral immune response
title Structural differences between the two human complement C4 isotypes affect the humoral immune response
title_full Structural differences between the two human complement C4 isotypes affect the humoral immune response
title_fullStr Structural differences between the two human complement C4 isotypes affect the humoral immune response
title_full_unstemmed Structural differences between the two human complement C4 isotypes affect the humoral immune response
title_short Structural differences between the two human complement C4 isotypes affect the humoral immune response
title_sort structural differences between the two human complement c4 isotypes affect the humoral immune response
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119129/
https://www.ncbi.nlm.nih.gov/pubmed/1732415

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