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The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin
FK-506 inhibits Ca(2+)-dependent transcription of lymphokine genes in T cells, and thereby acts as a powerful immunosuppressant. However, its potential therapeutic applications may be seriously limited by several side effects, including nephrotoxicity and neurotoxicity. At present, it is unclear whe...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1992
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119351/ https://www.ncbi.nlm.nih.gov/pubmed/1380976 |