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Engineered humanized dimeric forms of IgG are more effective antibodies
Humanized IgG1 M195 (HuG1-M195), a complementarity determining region- grafted recombinant monoclonal antibody, is reactive with CD33, an antigen expressed on myelogenous leukemia cells. M195 is in use in trials for the therapy of acute myelogenous leukemia. Since biological activity of IgG may depe...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1992
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119390/ https://www.ncbi.nlm.nih.gov/pubmed/1402660 |