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An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice
The pathogenicity of the human c-erbB-2 oncogene was evaluated in transgenic mice. A DNA sequence comprising the promoter-enhancer region of the MMTV LTR and a constitutively activated allele of the human c- erbB-2 growth factor receptor gene was introduced into the germ line of mice. Expression of...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1993
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119603/ https://www.ncbi.nlm.nih.gov/pubmed/8100231 |