Overexpression of the human MNB/DYRK1A gene induces formation of multinucleate cells through overduplication of the centrosome

BACKGROUND: Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But, the functions of the MNB/DYRK1A g...

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Detalles Bibliográficos
Autores principales: Funakoshi, Eishi, Hori, Takamitsu, Haraguchi, Tokuko, Hiraoka, Yasushi, Kudoh, Jun, Shimizu, Nobuyoshi, Ito, Fumiaki
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC212362/
https://www.ncbi.nlm.nih.gov/pubmed/12964950
http://dx.doi.org/10.1186/1471-2121-4-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC212362/
https://www.ncbi.nlm.nih.gov/pubmed/12964950
http://dx.doi.org/10.1186/1471-2121-4-12

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