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Blockade of NMDA receptor subtype NR2B prevents seizures but not apoptosis of dentate gyrus neurons in bacterial meningitis in infant rats

BACKGROUND: Excitotoxic neuronal injury by action of the glutamate receptors of the N-methyl-d-aspartate (NMDA) subtype have been implicated in the pathogenesis of brain damage as a consequence of bacterial meningitis. The most potent and selective blocker of NMDA receptors containing the NR2B subun...

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Detalles Bibliográficos
Autores principales: Kolarova, Anna, Ringer, Ralph, Täuber, Martin G, Leib, Stephen L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC212551/
https://www.ncbi.nlm.nih.gov/pubmed/13129439
http://dx.doi.org/10.1186/1471-2202-4-21