The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator β-catenin. Recent studies have demonstrated that axin, which coordinates β-catenin degradation, is itself degraded. Although the key mo...

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Detalles Bibliográficos
Autores principales: Lee, Ethan, Salic, Adrian, Krüger, Roland, Heinrich, Reinhart, Kirschner, Marc W
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC212691/
https://www.ncbi.nlm.nih.gov/pubmed/14551908
http://dx.doi.org/10.1371/journal.pbio.0000010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC212691/
https://www.ncbi.nlm.nih.gov/pubmed/14551908
http://dx.doi.org/10.1371/journal.pbio.0000010

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