Inhibition of Chk1 Kills Tetraploid Tumor Cells through a p53-Dependent Pathway

Tetraploidy constitutes an adaptation to stress and an intermediate step between euploidy and aneuploidy in oncogenesis. Tetraploid cells are particularly resistant against genotoxic stress including radiotherapy and chemotherapy. Here, we designed a strategy to preferentially kill tetraploid tumor...

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Detalles Bibliográficos
Autores principales: Vitale, Ilio, Galluzzi, Lorenzo, Vivet, Sonia, Nanty, Lisa, Dessen, Philippe, Senovilla, Laura, Olaussen, Ken A., Lazar, Vladimir, Prudhomme, Michelle, Golsteyn, Roy M., Castedo, Maria, Kroemer, Guido
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131784/
https://www.ncbi.nlm.nih.gov/pubmed/18159231
http://dx.doi.org/10.1371/journal.pone.0001337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131784/
https://www.ncbi.nlm.nih.gov/pubmed/18159231
http://dx.doi.org/10.1371/journal.pone.0001337

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