Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells

Matrix metalloproteinases (MMPs) regulate ductal morphogenesis, apoptosis, and neoplastic progression in mammary epithelial cells. To elucidate the direct effects of MMPs on mammary epithelium, we generated functionally normal cells expressing an inducible autoactivating stromelysin-1 (SL-1) transge...

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Detalles Bibliográficos
Autores principales: Lochter, André, Galosy, Sybille, Muschler, John, Freedman, Neal, Werb, Zena, Bissell, Mina J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132651/
https://www.ncbi.nlm.nih.gov/pubmed/9412478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132651/
https://www.ncbi.nlm.nih.gov/pubmed/9412478

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