The Tyrosine Kinase p56(lck) Mediates Activation of Swelling-induced Chloride Channels in Lymphocytes

Osmotic cell swelling activates Cl(−) channels to achieve anion efflux. In this study, we find that both the tyrosine kinase inhibitor herbimycin A and genetic knockout of p56(lck), a src-like tyrosine kinase, block regulatory volume decrease (RVD) in a human T cell line. Activation of a swelling-ac...

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Detalles Bibliográficos
Autores principales: Lepple-Wienhues, Albrecht, Szabò, Ildikò, Laun, Tilmann, Kaba, Nubia Kristen, Gulbins, Erich, Lang, Florian
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Regular Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132720/
https://www.ncbi.nlm.nih.gov/pubmed/9531565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132720/
https://www.ncbi.nlm.nih.gov/pubmed/9531565

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