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The Tyrosine Kinase p56(lck) Mediates Activation of Swelling-induced Chloride Channels in Lymphocytes

Osmotic cell swelling activates Cl(−) channels to achieve anion efflux. In this study, we find that both the tyrosine kinase inhibitor herbimycin A and genetic knockout of p56(lck), a src-like tyrosine kinase, block regulatory volume decrease (RVD) in a human T cell line. Activation of a swelling-ac...

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Detalles Bibliográficos
Autores principales:	Lepple-Wienhues, Albrecht, Szabò, Ildikò, Laun, Tilmann, Kaba, Nubia Kristen, Gulbins, Erich, Lang, Florian
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1998
Materias:	Regular Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132720/ https://www.ncbi.nlm.nih.gov/pubmed/9531565

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