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Filipin-dependent Inhibition of Cholera Toxin: Evidence for Toxin Internalization and Activation through Caveolae-like Domains

The mechanism by which cholera toxin (CT) is internalized from the plasma membrane before its intracellular reduction and subsequent activation of adenylyl cyclase is not well understood. Ganglioside G(M1), the receptor for CT, is predominantly clustered in detergent-insoluble glycolipid rafts and i...

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Detalles Bibliográficos
Autores principales: Orlandi, Palmer A., Fishman, Peter H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132770/
https://www.ncbi.nlm.nih.gov/pubmed/9585410