Disruption of the Talin Gene Compromises Focal Adhesion Assembly in Undifferentiated but Not Differentiated Embryonic Stem Cells

We have used gene disruption to isolate two talin (−/−) ES cell mutants that contain no intact talin. The undifferentiated cells (a) were unable to spread on gelatin or laminin and grew as rounded colonies, although they were able to spread on fibronectin (b) showed reduced adhesion to laminin, but...

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Detalles Bibliográficos
Autores principales: Priddle, Helen, Hemmings, Lance, Monkley, Susan, Woods, Alison, Patel, Bipin, Sutton, Deborah, Dunn, Graham A., Zicha, Daniel, Critchley, David R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132864/
https://www.ncbi.nlm.nih.gov/pubmed/9722622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132864/
https://www.ncbi.nlm.nih.gov/pubmed/9722622

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