Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol, cytochrome c binds to the CED-4 homologue, Apaf-1, thereby triggering Apaf-1–mediated activation of caspase-9. Caspase-9 is thought to propagate the death signal by triggeri...

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Detalles Bibliográficos
Autores principales: Slee, Elizabeth A., Harte, Mary T., Kluck, Ruth M., Wolf, Beni B., Casiano, Carlos A., Newmeyer, Donald D., Wang, Hong-Gang, Reed, John C., Nicholson, Donald W., Alnemri, Emad S., Green, Douglas R., Martin, Seamus J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Regular Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132895/
https://www.ncbi.nlm.nih.gov/pubmed/9922454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132895/
https://www.ncbi.nlm.nih.gov/pubmed/9922454

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