Overexpression of Protein Kinase C β(II) Induces Colonic Hyperproliferation and Increased Sensitivity to Colon Carcinogenesis

Protein kinase C β(II) (PKC β(II)) has been implicated in proliferation of the intestinal epithelium. To investigate PKC β(II) function in vivo, we generated transgenic mice that overexpress PKC β(II) in the intestinal epithelium. Transgenic PKC β(II) mice exhibit hyperproliferation of the colonic e...

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Detalles Bibliográficos
Autores principales: Murray, Nicole R., Davidson, Laurie A., Chapkin, Robert S., Clay Gustafson, W., Schattenberg, Diane G., Fields, Alan P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Regular Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133187/
https://www.ncbi.nlm.nih.gov/pubmed/10330400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133187/
https://www.ncbi.nlm.nih.gov/pubmed/10330400

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