A Mechanism Misregulating p27 in Tumors Discovered in a Functional Genomic Screen

The cyclin-dependent kinase inhibitor p27(KIP1) is a tumor suppressor gene in mice, and loss of p27 protein is a negative prognostic indicator in human cancers. Unlike other tumor suppressors, the p27 gene is rarely mutated in tumors. Therefore misregulation of p27, rather than loss of the gene, is...

Descripción completa

Detalles Bibliográficos
Autores principales: Garrett-Engele, Carrie M, Tasch, Michael A, Hwang, Harry C, Fero, Matthew L, Perlmutter, Roger M, Clurman, Bruce E, Roberts, James M
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134944/
https://www.ncbi.nlm.nih.gov/pubmed/18069898
http://dx.doi.org/10.1371/journal.pgen.0030219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134944/
https://www.ncbi.nlm.nih.gov/pubmed/18069898
http://dx.doi.org/10.1371/journal.pgen.0030219

Ejemplares similares