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Stereochemical Criteria for Prediction of the Effects of Proline Mutations on Protein Stability
When incorporated into a polypeptide chain, proline (Pro) differs from all other naturally occurring amino acid residues in two important respects. The φ dihedral angle of Pro is constrained to values close to −65° and Pro lacks an amide hydrogen. Consequently, mutations which result in introduction...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134964/ https://www.ncbi.nlm.nih.gov/pubmed/18069886 http://dx.doi.org/10.1371/journal.pcbi.0030241 |