THE EFFECT OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE METABOLISM : I. THE EFFECT ON ENZYMES

Nitrogen mustards are powerful inhibitors for choline oxidase, acetylcholine esterase, and choline acetylase, half-inhibition of the first enzyme being produced with concentrations around 1 x 10(–6) M; i.e., ten times less than the LD(50) values. Acetylcholine esterase and choline acetylase required...

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Detalles Bibliográficos
Autores principales: Barron, E. S. Guzman, Bartlett, Grant R., Miller, Zelma Baker
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1948
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135790/
https://www.ncbi.nlm.nih.gov/pubmed/18858640
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author Barron, E. S. Guzman
Bartlett, Grant R.
Miller, Zelma Baker
author_facet Barron, E. S. Guzman
Bartlett, Grant R.
Miller, Zelma Baker
author_sort Barron, E. S. Guzman
collection PubMed
description Nitrogen mustards are powerful inhibitors for choline oxidase, acetylcholine esterase, and choline acetylase, half-inhibition of the first enzyme being produced with concentrations around 1 x 10(–6) M; i.e., ten times less than the LD(50) values. Acetylcholine esterase and choline acetylase required higher concentrations. This inhibition seems to be due to the structural similarity of the ethylenimonium derivatives with choline and acetylcholine. A list of enzyme systems inhibited by nitrogen mustards is given.
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spelling pubmed-21357902008-04-18 THE EFFECT OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE METABOLISM : I. THE EFFECT ON ENZYMES Barron, E. S. Guzman Bartlett, Grant R. Miller, Zelma Baker J Exp Med Article Nitrogen mustards are powerful inhibitors for choline oxidase, acetylcholine esterase, and choline acetylase, half-inhibition of the first enzyme being produced with concentrations around 1 x 10(–6) M; i.e., ten times less than the LD(50) values. Acetylcholine esterase and choline acetylase required higher concentrations. This inhibition seems to be due to the structural similarity of the ethylenimonium derivatives with choline and acetylcholine. A list of enzyme systems inhibited by nitrogen mustards is given. The Rockefeller University Press 1948-06-01 /pmc/articles/PMC2135790/ /pubmed/18858640 Text en Copyright © Copyright, 1948, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Barron, E. S. Guzman
Bartlett, Grant R.
Miller, Zelma Baker
THE EFFECT OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE METABOLISM : I. THE EFFECT ON ENZYMES
title THE EFFECT OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE METABOLISM : I. THE EFFECT ON ENZYMES
title_full THE EFFECT OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE METABOLISM : I. THE EFFECT ON ENZYMES
title_fullStr THE EFFECT OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE METABOLISM : I. THE EFFECT ON ENZYMES
title_full_unstemmed THE EFFECT OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE METABOLISM : I. THE EFFECT ON ENZYMES
title_short THE EFFECT OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE METABOLISM : I. THE EFFECT ON ENZYMES
title_sort effect of nitrogen mustards on enzymes and tissue metabolism : i. the effect on enzymes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135790/
https://www.ncbi.nlm.nih.gov/pubmed/18858640
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