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MECHANISMS INVOLVED IN THE ANTIMYCOBACTERIAL ACTIVITY OF CERTAIN BASIC PEPTIDES
The antimycobacterial activity of thymus peptide under certain conditions in vitro can be partially neutralized by increasing the concentration of sulfate ions in the medium, and to a lesser extent by the addition of certain organic compounds which contain sulfur. It is suggested that thymus peptide...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1954
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136323/ https://www.ncbi.nlm.nih.gov/pubmed/13118065 |
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author | Hirsch, James G. |
author_facet | Hirsch, James G. |
author_sort | Hirsch, James G. |
collection | PubMed |
description | The antimycobacterial activity of thymus peptide under certain conditions in vitro can be partially neutralized by increasing the concentration of sulfate ions in the medium, and to a lesser extent by the addition of certain organic compounds which contain sulfur. It is suggested that thymus peptide suppresses the growth of tubercle bacilli by interfering with the normal sulfur metabolism of these microorganisms. Polylysine peptide and pituitary adrenocorticotropic hormone, other basic peptides derived from animal tissues, also inhibit the multiplication of tubercle bacilli in vitro, and their antimycobacterial activity is also antagonized by sulfate ions. Basic peptide hormones prepared from the posterior pituitary gland do not affect the growth of acid-fast bacteria under the conditions of the test. |
format | Text |
id | pubmed-2136323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1954 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21363232008-04-17 MECHANISMS INVOLVED IN THE ANTIMYCOBACTERIAL ACTIVITY OF CERTAIN BASIC PEPTIDES Hirsch, James G. J Exp Med Article The antimycobacterial activity of thymus peptide under certain conditions in vitro can be partially neutralized by increasing the concentration of sulfate ions in the medium, and to a lesser extent by the addition of certain organic compounds which contain sulfur. It is suggested that thymus peptide suppresses the growth of tubercle bacilli by interfering with the normal sulfur metabolism of these microorganisms. Polylysine peptide and pituitary adrenocorticotropic hormone, other basic peptides derived from animal tissues, also inhibit the multiplication of tubercle bacilli in vitro, and their antimycobacterial activity is also antagonized by sulfate ions. Basic peptide hormones prepared from the posterior pituitary gland do not affect the growth of acid-fast bacteria under the conditions of the test. The Rockefeller University Press 1954-01-01 /pmc/articles/PMC2136323/ /pubmed/13118065 Text en Copyright © Copyright, 1954, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Hirsch, James G. MECHANISMS INVOLVED IN THE ANTIMYCOBACTERIAL ACTIVITY OF CERTAIN BASIC PEPTIDES |
title | MECHANISMS INVOLVED IN THE ANTIMYCOBACTERIAL ACTIVITY OF CERTAIN BASIC PEPTIDES |
title_full | MECHANISMS INVOLVED IN THE ANTIMYCOBACTERIAL ACTIVITY OF CERTAIN BASIC PEPTIDES |
title_fullStr | MECHANISMS INVOLVED IN THE ANTIMYCOBACTERIAL ACTIVITY OF CERTAIN BASIC PEPTIDES |
title_full_unstemmed | MECHANISMS INVOLVED IN THE ANTIMYCOBACTERIAL ACTIVITY OF CERTAIN BASIC PEPTIDES |
title_short | MECHANISMS INVOLVED IN THE ANTIMYCOBACTERIAL ACTIVITY OF CERTAIN BASIC PEPTIDES |
title_sort | mechanisms involved in the antimycobacterial activity of certain basic peptides |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136323/ https://www.ncbi.nlm.nih.gov/pubmed/13118065 |
work_keys_str_mv | AT hirschjamesg mechanismsinvolvedintheantimycobacterialactivityofcertainbasicpeptides |