The Influence of Huntingtin Protein Size on Nuclear Localization and Cellular Toxicity

Huntington disease is an autosomal dominant neurodegenerative disorder caused by the pathological expansion of a polyglutamine tract. In this study we directly assess the influence of protein size on the formation and subcellular localization of huntingtin aggregates. We have created numerous deleti...

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Detalles Bibliográficos
Autores principales: Hackam, Abigail S., Singaraja, Roshni, Wellington, Cheryl L., Metzler, Martina, McCutcheon, Krista, Zhang, Taiqi, Kalchman, Michael, Hayden, Michael R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137174/
https://www.ncbi.nlm.nih.gov/pubmed/9606203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137174/
https://www.ncbi.nlm.nih.gov/pubmed/9606203

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