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The Influence of Huntingtin Protein Size on Nuclear Localization and Cellular Toxicity
Huntington disease is an autosomal dominant neurodegenerative disorder caused by the pathological expansion of a polyglutamine tract. In this study we directly assess the influence of protein size on the formation and subcellular localization of huntingtin aggregates. We have created numerous deleti...
Autores principales: | Hackam, Abigail S., Singaraja, Roshni, Wellington, Cheryl L., Metzler, Martina, McCutcheon, Krista, Zhang, Taiqi, Kalchman, Michael, Hayden, Michael R. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1998
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137174/ https://www.ncbi.nlm.nih.gov/pubmed/9606203 |
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