Lack of Foxp3 function and expression in the thymic epithelium

Foxp3 is essential for the commitment of differentiating thymocytes to the regulatory CD4(+) T (T reg) cell lineage. In humans and mice with a genetic Foxp3 deficiency, absence of this critical T reg cell population was suggested to be responsible for the severe autoimmune lesions. Recently, it has...

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Detalles Bibliográficos
Autores principales: Liston, Adrian, Farr, Andrew G., Chen, Zhibin, Benoist, Christophe, Mathis, Diane, Manley, Nancy R., Rudensky, Alexander Y.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137899/
https://www.ncbi.nlm.nih.gov/pubmed/17353370
http://dx.doi.org/10.1084/jem.20062465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137899/
https://www.ncbi.nlm.nih.gov/pubmed/17353370
http://dx.doi.org/10.1084/jem.20062465

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