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Lack of Foxp3 function and expression in the thymic epithelium
Foxp3 is essential for the commitment of differentiating thymocytes to the regulatory CD4(+) T (T reg) cell lineage. In humans and mice with a genetic Foxp3 deficiency, absence of this critical T reg cell population was suggested to be responsible for the severe autoimmune lesions. Recently, it has...
Autores principales: | Liston, Adrian, Farr, Andrew G., Chen, Zhibin, Benoist, Christophe, Mathis, Diane, Manley, Nancy R., Rudensky, Alexander Y. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137899/ https://www.ncbi.nlm.nih.gov/pubmed/17353370 http://dx.doi.org/10.1084/jem.20062465 |
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