Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus

Mouse strains AcB55 and AcB61 are resistant to malaria by virtue of a mutation in erythrocyte pyruvate kinase (Pklr(I90N)). Linkage analysis in [AcB55 × A/J] F2 mice detected a second locus (Char9; logarithm of odds = 4.74) that regulates the blood-stage replication of Plasmodium chabaudi AS indepen...

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Detalles Bibliográficos
Autores principales: Min-Oo, Gundula, Fortin, Anny, Pitari, Giuseppina, Tam, Mifong, Stevenson, Mary M., Gros, Philippe
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137903/
https://www.ncbi.nlm.nih.gov/pubmed/17312006
http://dx.doi.org/10.1084/jem.20061252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137903/
https://www.ncbi.nlm.nih.gov/pubmed/17312006
http://dx.doi.org/10.1084/jem.20061252

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