A novel pathway down-modulating T cell activation involves HPK-1–dependent recruitment of 14-3-3 proteins on SLP-76

The SH2 domain–containing leukocyte protein of 76 kD (SLP-76) is a pivotal element of the signaling machinery controlling T cell receptor (TCR)-mediated activation. Here, we identify 14-3-3ɛ and ζ proteins as SLP-76 binding partners. This interaction was induced by TCR ligation and required phosphor...

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Detalles Bibliográficos
Autores principales: Bartolo, Vincenzo Di, Montagne, Benjamin, Salek, Mogjiborahman, Jungwirth, Britta, Carrette, Florent, Fourtane, Julien, Sol-Foulon, Nathalie, Michel, Frédérique, Schwartz, Olivier, Lehmann, Wolf D., Acuto, Oreste
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137917/
https://www.ncbi.nlm.nih.gov/pubmed/17353368
http://dx.doi.org/10.1084/jem.20062066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137917/
https://www.ncbi.nlm.nih.gov/pubmed/17353368
http://dx.doi.org/10.1084/jem.20062066

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