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STUDIES ON THE MECHANISM OF TUMOR INHIBITION BY L-ASPARAGINASE : EFFECTS OF THE ENZYME ON ASPARAGINE LEVELS IN THE BLOOD, NORMAL TISSUES, AND 6C3HED LYMPHOMAS OF MICE: DIFFERENCES IN ASPARAGINE FORMATION AND UTILIZATION IN ASPARAGINASE-SENSITIVE AND -RESISTANT LYMPHOMA CELLS
L-asparaginases of agouti serum and Escherichia coli cause a profound lowering in the level of free asparagine in the blood of treated mice and also in the tissues. During treatment, normal tissues and resistant 6C3HED lymphomas survive unharmed with intracellular asparagine levels which are critica...
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| Formato: | Texto |
| Lenguaje: | English |
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The Rockefeller University Press
1968
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138499/ https://www.ncbi.nlm.nih.gov/pubmed/4871211 |