THE ROLE OF IMMUNOGENICITY IN THE INDUCTION OF TOLERANCE WITH CONJUGATES OF ARSANILIC ACID

A number of azobenzenearsonate (ABA) conjugates have been prepared and tested for ability to react with antibody, to sensitize for hapten-specific delayed hypersensitivity and to induce hapten-specific unresponsiveness. All conjugates tested by in vitro or in vivo methods show a capacity to react wi...

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Autores principales: Collotti, Clelia, Leskowitz, Sidney
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1970
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138824/
https://www.ncbi.nlm.nih.gov/pubmed/5413329
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author Collotti, Clelia
Leskowitz, Sidney
author_facet Collotti, Clelia
Leskowitz, Sidney
author_sort Collotti, Clelia
collection PubMed
description A number of azobenzenearsonate (ABA) conjugates have been prepared and tested for ability to react with antibody, to sensitize for hapten-specific delayed hypersensitivity and to induce hapten-specific unresponsiveness. All conjugates tested by in vitro or in vivo methods show a capacity to react with preformed antibody. Conjugates of L-amino acid polymers are immunogenic and induce tolerance. Conjugates of D-amino acid polymers or conjugates with high density of ABA groups are nonimmunogenic and fail to induce tolerance. Since paired D- and L-polymer conjugates react comparably with preformed antibody but differ markedly in tolerance induction, it is argued that combination with an antibody-like receptor molecule on the surface of an immune-competent cell is not a sufficient condition for tolerance. The lack of effectiveness of sterically crowded conjugates as well as D-polymer conjugates argues for a preliminary biologic "processing" of antigen necessary for induction of immunity or tolerance. Such a processing event might well involve enzymatic attack on the antigen.
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spelling pubmed-21388242008-04-17 THE ROLE OF IMMUNOGENICITY IN THE INDUCTION OF TOLERANCE WITH CONJUGATES OF ARSANILIC ACID Collotti, Clelia Leskowitz, Sidney J Exp Med Article A number of azobenzenearsonate (ABA) conjugates have been prepared and tested for ability to react with antibody, to sensitize for hapten-specific delayed hypersensitivity and to induce hapten-specific unresponsiveness. All conjugates tested by in vitro or in vivo methods show a capacity to react with preformed antibody. Conjugates of L-amino acid polymers are immunogenic and induce tolerance. Conjugates of D-amino acid polymers or conjugates with high density of ABA groups are nonimmunogenic and fail to induce tolerance. Since paired D- and L-polymer conjugates react comparably with preformed antibody but differ markedly in tolerance induction, it is argued that combination with an antibody-like receptor molecule on the surface of an immune-competent cell is not a sufficient condition for tolerance. The lack of effectiveness of sterically crowded conjugates as well as D-polymer conjugates argues for a preliminary biologic "processing" of antigen necessary for induction of immunity or tolerance. Such a processing event might well involve enzymatic attack on the antigen. The Rockefeller University Press 1970-02-28 /pmc/articles/PMC2138824/ /pubmed/5413329 Text en Copyright © 1970 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Collotti, Clelia
Leskowitz, Sidney
THE ROLE OF IMMUNOGENICITY IN THE INDUCTION OF TOLERANCE WITH CONJUGATES OF ARSANILIC ACID
title THE ROLE OF IMMUNOGENICITY IN THE INDUCTION OF TOLERANCE WITH CONJUGATES OF ARSANILIC ACID
title_full THE ROLE OF IMMUNOGENICITY IN THE INDUCTION OF TOLERANCE WITH CONJUGATES OF ARSANILIC ACID
title_fullStr THE ROLE OF IMMUNOGENICITY IN THE INDUCTION OF TOLERANCE WITH CONJUGATES OF ARSANILIC ACID
title_full_unstemmed THE ROLE OF IMMUNOGENICITY IN THE INDUCTION OF TOLERANCE WITH CONJUGATES OF ARSANILIC ACID
title_short THE ROLE OF IMMUNOGENICITY IN THE INDUCTION OF TOLERANCE WITH CONJUGATES OF ARSANILIC ACID
title_sort role of immunogenicity in the induction of tolerance with conjugates of arsanilic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2138824/
https://www.ncbi.nlm.nih.gov/pubmed/5413329
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