A Role for Cdk2 Kinase in Negatively Regulating DNA Replication during S Phase of the Cell Cycle

Using cell-free extracts made from Xenopus eggs, we show that cdk2-cyclin E and A kinases play an important role in negatively regulating DNA replication. Specifically, we demonstrate that the cdk2 kinase concentration surrounding chromatin in extracts increases 200-fold once the chromatin is assemb...

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Detalles Bibliográficos
Autores principales: Hua, Xuequn Helen, Yan, Hong, Newport, John
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139856/
https://www.ncbi.nlm.nih.gov/pubmed/9105046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139856/
https://www.ncbi.nlm.nih.gov/pubmed/9105046

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