Transmembrane Domain Sequence Requirements for Activation of the p185(c-neu) Receptor Tyrosine Kinase

The receptor tyrosine kinase p185(c-neu) can be constitutively activated by the transmembrane domain mutation Val(664)→ Glu, found in the oncogenic mutant p185(neu). This mutation is predicted to allow intermolecular hydrogen bonding and receptor dimerization. Understanding the activation of p185(c-...

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Detalles Bibliográficos
Autores principales: Chen, Lucinda I., Webster, Melanie K., Meyer, April N., Donoghue, Daniel J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139875/
https://www.ncbi.nlm.nih.gov/pubmed/9151669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139875/
https://www.ncbi.nlm.nih.gov/pubmed/9151669

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