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Transmembrane Domain Sequence Requirements for Activation of the p185(c-neu) Receptor Tyrosine Kinase
The receptor tyrosine kinase p185(c-neu) can be constitutively activated by the transmembrane domain mutation Val(664)→ Glu, found in the oncogenic mutant p185(neu). This mutation is predicted to allow intermolecular hydrogen bonding and receptor dimerization. Understanding the activation of p185(c-...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1997
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139875/ https://www.ncbi.nlm.nih.gov/pubmed/9151669 |