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Bi-transgenic Mice Reveal that K-ras(Val12) Augments a p53-independent Apoptosis When Small Intestinal Villus Enterocytes Reenter the Cell Cycle
Studies in cell culture systems have indicated that oncogenic forms of Ras can affect apoptosis. Activating mutations of Ras occur in ∼30% of all human tumors and 50% of colorectal carcinomas. Since these mutations appear at early or intermediate stages in multistep journeys to neoplasia, an effect...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1997
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139936/ https://www.ncbi.nlm.nih.gov/pubmed/9214390 |