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Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC

Phosphorylation at unspecified sites is known to regulate the life cycle (assembly, gating, and turnover) of the gap junction protein, Cx43. In this paper, we show that Cx43 is phosphorylated on S365 in cultured cells and heart tissue. Nuclear magnetic resonance structural studies of the C-terminal...

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Detalles Bibliográficos
Autores principales: Solan, Joell L., Marquez-Rosado, Lucrecia, Sorgen, Paul L., Thornton, Perry J., Gafken, Philip R., Lampe, Paul D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140020/
https://www.ncbi.nlm.nih.gov/pubmed/18086922
http://dx.doi.org/10.1083/jcb.200707060