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Transglutaminase 2 Undergoes a Large Conformational Change upon Activation

Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathogenesis of celiac sprue. Although vertebrate transglutaminases have been...

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Detalles Bibliográficos
Autores principales: Pinkas, Daniel M, Strop, Pavel, Brunger, Axel T, Khosla, Chaitan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140088/
https://www.ncbi.nlm.nih.gov/pubmed/18092889
http://dx.doi.org/10.1371/journal.pbio.0050327