THE KINETICS OF MULTIPLE ENZYME INHIBITION

The adaptive fermentation of galactose by yeast is inhibited by fluoride and azide. At sufficiently low concentrations, however, it is stimulated. From a mathematical analysis, using the known fact that fluoride inhibits the enzymes enolase and adenosinetriphosphatase, it is possible to infer the ex...

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Detalles Bibliográficos
Autor principal: Reiner, John M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1947
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142837/
https://www.ncbi.nlm.nih.gov/pubmed/19873501
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author Reiner, John M.
author_facet Reiner, John M.
author_sort Reiner, John M.
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description The adaptive fermentation of galactose by yeast is inhibited by fluoride and azide. At sufficiently low concentrations, however, it is stimulated. From a mathematical analysis, using the known fact that fluoride inhibits the enzymes enolase and adenosinetriphosphatase, it is possible to infer the existence of such stimulation. Conditions for this effect are derived which relate the sensitivities of the enzymes to the poison with the rate constants of the various reactions in the fermentation chain.
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spelling pubmed-21428372008-04-23 THE KINETICS OF MULTIPLE ENZYME INHIBITION Reiner, John M. J Gen Physiol Article The adaptive fermentation of galactose by yeast is inhibited by fluoride and azide. At sufficiently low concentrations, however, it is stimulated. From a mathematical analysis, using the known fact that fluoride inhibits the enzymes enolase and adenosinetriphosphatase, it is possible to infer the existence of such stimulation. Conditions for this effect are derived which relate the sensitivities of the enzymes to the poison with the rate constants of the various reactions in the fermentation chain. The Rockefeller University Press 1947-03-20 /pmc/articles/PMC2142837/ /pubmed/19873501 Text en Copyright © Copyright, 1947, by The Rockefeller Institute for Medical Research This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Reiner, John M.
THE KINETICS OF MULTIPLE ENZYME INHIBITION
title THE KINETICS OF MULTIPLE ENZYME INHIBITION
title_full THE KINETICS OF MULTIPLE ENZYME INHIBITION
title_fullStr THE KINETICS OF MULTIPLE ENZYME INHIBITION
title_full_unstemmed THE KINETICS OF MULTIPLE ENZYME INHIBITION
title_short THE KINETICS OF MULTIPLE ENZYME INHIBITION
title_sort kinetics of multiple enzyme inhibition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142837/
https://www.ncbi.nlm.nih.gov/pubmed/19873501
work_keys_str_mv AT reinerjohnm thekineticsofmultipleenzymeinhibition
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