Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria

BACKGROUND: Mycolic acids are a complex mixture of branched, long-chain fatty acids, representing key components of the highly hydrophobic mycobacterial cell wall. Pathogenic mycobacteria carry mycolic acid sub-types that contain cyclopropane rings. Double bonds at specific sites on mycolic acid pre...

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Detalles Bibliográficos
Autores principales: Alahari, Anuradha, Trivelli, Xavier, Guérardel, Yann, Dover, Lynn G., Besra, Gurdyal S., Sacchettini, James C., Reynolds, Robert C., Coxon, Geoffrey D., Kremer, Laurent
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147073/
https://www.ncbi.nlm.nih.gov/pubmed/18094751
http://dx.doi.org/10.1371/journal.pone.0001343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147073/
https://www.ncbi.nlm.nih.gov/pubmed/18094751
http://dx.doi.org/10.1371/journal.pone.0001343

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