Detection by Epitope-defined Monoclonal Antibodies of Werner DNA Helicases in the Nucleoplasm and Their Upregulation by Cell Transformation and Immortalization

We prepared several monoclonal antibodies (mAbs) specific for the NH(2)- and COOH-terminal regions of the DNA helicase (WRN helicase) responsible for Werner's syndrome known as a premature aging disease. With these antibodies, we detected by immunoblot analysis the endogenous WRN helicase of a...

Descripción completa

Detalles Bibliográficos
Autores principales: Shiratori, Miwa, Sakamoto, Sakae, Suzuki, Noriyuki, Tokutake, Yoshiki, Kawabe, Yoichi, Enomoto, Takemi, Sugimoto, Masanobu, Goto, Makoto, Matsumoto, Takehisa, Furuichi, Yasuhiro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148112/
https://www.ncbi.nlm.nih.gov/pubmed/9885239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148112/
https://www.ncbi.nlm.nih.gov/pubmed/9885239

Ejemplares similares