Absence of Basement Membranes after Targeting the LAMC1 Gene Results in Embryonic Lethality Due to Failure of Endoderm Differentiation

The LAMC1 gene coding for the laminin γ1 subunit was targeted by homologous recombination in mouse embryonic stem cells. Mice heterozygous for the mutation had a normal phenotype and were fertile, whereas homozygous mutant embryos did not survive beyond day 5.5 post coitum. These embryos lacked base...

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Detalles Bibliográficos
Autores principales: Smyth, Neil, Vatansever, H. Seda, Murray, Patricia, Meyer, Michael, Frie, Christian, Paulsson, Mats, Edgar, David
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148127/
https://www.ncbi.nlm.nih.gov/pubmed/9885251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148127/
https://www.ncbi.nlm.nih.gov/pubmed/9885251

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