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p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells

Proliferation in mammalian cells is controlled primarily in the G1-phase of the cell cycle through the action of the G1 cyclin–dependent kinases, CDK4 and CDK2. To explore the mechanism of cellular response to extrinsic factors, specific loss of function mutations were generated in two negative regu...

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Detalles Bibliográficos
Autores principales: Brugarolas, James, Bronson, Roderick T., Jacks, Tyler
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148461/
https://www.ncbi.nlm.nih.gov/pubmed/9548727