Frequent and heterogeneous expression of cyclin-dependent kinase inhibitor WAF1/p21 protein and mRNA in urothelial carcinoma.

The inhibitor of cyclin-dependent kinases WAF1/p21 has been shown to mediate cell cycle arrest by p53 and other factors. We have studied its expression in urothelial carcinoma. Immunohistochemistry of paraffin-embedded tissues revealed no detectable p21 protein in normal mucosa, whereas 8 of 17 (47%...

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Detalles Bibliográficos
Autores principales: Clasen, S., Schulz, W. A., Gerharz, C. D., Grimm, M. O., Christoph, F., Schmitz-Dräger, B. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2149915/
https://www.ncbi.nlm.nih.gov/pubmed/9484805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2149915/
https://www.ncbi.nlm.nih.gov/pubmed/9484805

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