Dose-limiting neurotoxicity in a phase I study of penclomedine (NSC 388720, CRC 88-04), a synthetic alpha-picoline derivative, administered intravenously.

3,5-Dichloro-2,4-dimethoxy-6-(trichloromethyl)pyridine (penclomedine, NSC 338720, CRC 88-04) is an alpha-picoline derivative with anti-tumour activity in preclinical models. Penclomedine administration by 1-h intravenous infusion on 5 consecutive days was repeated 3 weekly in the absence of dose-lim...

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Detalles Bibliográficos
Autores principales: Jodrell, D. I., Bowman, A., Stewart, M., Dunlop, N., French, R., MacLellan, A., Cummings, J., Smyth, J. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2149952/
https://www.ncbi.nlm.nih.gov/pubmed/9514062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2149952/
https://www.ncbi.nlm.nih.gov/pubmed/9514062

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